Fidelity of G protein -subunit association by the G protein -subunit-like domains of RGS6, RGS7, and RGS11
نویسندگان
چکیده
منابع مشابه
Fidelity of G protein b-subunit association by the G protein g-subunit-like domains of RGS6, RGS7, and RGS11
Several regulators of G protein signaling (RGS) proteins contain a G protein g-subunit-like (GGL) domain, which, as we have shown, binds to Gb5 subunits. Here, we extend our original findings by describing another GGLdomain-containing RGS, human RGS6. When RGS6 is coexpressed with different Gb subunits, only RGS6 and Gb5 interact. The expression of mRNA for RGS6 and Gb5 in human tissues overlap...
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A structurally divergent G-protein beta subunit expressed in brain and retina, Gbeta5, exhibits functional specialization in its protein-protein interactions in vitro. In retina, Gbeta5 has been isolated in a soluble complex with regulator of G-protein signaling RGS7. The function and molecular associations of Gbeta5 in brain are unknown. To identify tightly bound proteins associated with Gbeta...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1999
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.96.11.6489